LOKREN is used for:
Treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.
LOKREN is a beta-blocker. It works by slowing down the heart and decreasing the amount of blood it pumps out. This helps to decrease blood pressure, helps the heart pump more efficiently, and reduces the workload on the heart.
Do NOT use LOKREN if:
- you are allergic to any ingredient in LOKREN
- you have greater than first-degree heart block, shock caused by severe heart problems, uncontrolled heart failure, or a very slow heartbeat
Contact your doctor or health care provider right away if any of these apply to you.
Before using LOKREN:
Some medical conditions may interact with LOKREN. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine (eg, medicines to treat colds or congestion), herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances or are taking medicine for allergies
- if you have or have ever had an adrenal gland tumor (pheochromocytoma), lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease, chronic bronchitis, emphysema), psoriasis, glaucoma or increased pressure in the eye, diabetes, kidney or liver problems, low blood sugar, or overactive thyroid
- if you have a history of chest pain or angina, heart problems (eg, heart failure, slow or irregular heartbeat, heart attack), low blood pressure, blood circulation problems, or blood vessel problems (including those in the brain or heart)
- if you are on dialysis or are scheduled to have surgery
Some MEDICINES MAY INTERACT with LOKREN. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Antiarrhythmics (eg, amiodarone, disopyramide, flecainide), calcium channel blockers (eg, mibefradil, nifedipine, verapamil), digoxin, fingolimod, or mefloquine because the risk of side effects, such as slow or irregular heartbeat, heart failure, or very low blood pressure, may be increased
- Clonidine because high blood pressure may occur in some cases, especially if you suddenly stop taking clonidine while taking LOKREN
- Catecholamine-depleting agents (eg, reserpine) because they may increase the risk of LOKREN's side effects
- Indomethacin because it may decrease LOKREN's effectiveness
- Alfuzosin, insulin, or prazosin because the risk of their side effects may be increased by LOKREN
This may not be a complete list of all interactions that may occur. Ask your health care provider if LOKREN may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.